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Annual Report on the External Quality Assessment Scheme for Biochemical Genetics in Korea (2014)
J Lab Med Qual Assur 2015;37:56-63
Published online June 30, 2015
© 2015 Korean Association of Quality Assurance for Clinical Laboratory.

Soo-Youn Lee1, Ok Ja Ji1, Gye Cheol Kwon2, Jong- Won Kim1, Hyung-Doo Park1, Junghan Song3, Sang-Guk Lee4, Yong- Wha Lee5, Eun Hee Lee6, Sail Chun7, and Tae Youn Choi8, as Biochemical Genetics Subcommittee, The Korean Association of External Quality Assessment Service

1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; 2Department of Laboratory Medicine, Chungnam National University Hospital, Daejeon; 3Department of Laboratory Medicine, Seoul Natinal University Bundang Hospital, Seongnam; 4Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul; 5Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon; 6Green Cross Laboratories, Yongin; 7Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine; 8Department of Laboratory Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, Korea
Correspondence to: Soo-Youn Lee
Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Korea
Tel:+82-2-3410-1834
Fax: +82-2-3410-2719
E-mail: suddenbz@skku.edu
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Two trials of external quality assessment (EQA) of conventional newborn screening tests for phenylketonuria, galactosaemia, congenital adrenal hyperplasia, maple syrup urine disease, homocystinuria, and congenital hypothyroidism, as well as newborn screening tests were performed using tandem mass spectrometry in 2014. A total of 39 specimens in the form of dried blood spots were distributed to 16 laboratories and the response rate of these laboratories was 100%. Screening tests for phenylketonuria and congenital hypothyroidism did not meet the accepted performance criteria in some laboratories. The mean, standard deviation, coefficient of variation, median, and cut-offs were evaluated for each analyte in the newborn screening tests. Two trials of EQA for the analyses of methylmalonic acid, vanillylmandelic acid, catecholamines, metanephrines, organic acids, and amino acids were also performed. A well-designed EQA program and continuous education would improve the performance of biochemical genetic testing.
(J Lab Med Qual Assur 2015;37:56-63)
Keywords : External quality assessment, Newborn screening, Tandem mass spectrometry, Biochemical genetics
References
  1. Song J, Kwon KC, Kim JH, Kim JW, Min WK, Lee SY, et al. Annual report on external quality assessment in metabolic disorders in Korea (2007). J Lab Med Qual Assur 2008;30:151-66.
  2. Lee SY, Kwon KC, Kim JH, Kim JW, Park BT, Park HD, et al. Annual report on external quality assessment in biochemical genetics in Korea (2011). J Lab Med Qual Assur 2012;34:S25-49.
  3. Lee SY, Kwon KC, Kim JH, Kim JW, Park BT, Park HD, et al. Annual report on external quality assessment in biochemical genetics in Korea (2012). J Lab Med Qual Assur 2013;35:S29-63.
  4. Lee SY; Biochemical Genetics Subcommittee, The Korean Association of Quality Assurance for Clinical Laboratory. Annual report on external quality assessment of biochemical genetics in Korea (2013). J Lab Med Qual Assur 2014;36:64-70.
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