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씪諛섑삁븸寃궗 봽濡쒓렇옩 떊鍮숇룄議곗궗 寃곌낵蹂닿퀬(2016)
Annual Report on the External Quality Assessment Scheme for Routine Hematology in Korea (2016)
J Lab Med Qual Assur 2017;39:53-60
Published online June 30, 2017
© 2017 Korean Association of External Quality Assessment Service.

씠쁺寃
Young Kyung Lee

븳由쇰븰援 쓽怨쇰븰 븳由쇰븰援먯꽦떖蹂묒썝 吏꾨떒寃궗쓽븰怨

Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
Correspondence to: Young Kyung Lee Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang 14068, Korea Tel: +82-31-380-3930 Fax: +82-31-380-3934 E-mail: lyoungk@hallym.or.kr
씠쁺寃 슦)14068 寃쎄린룄 븞뼇떆 룞븞援 愿룊濡 170踰덇만 22, 븳由쇰븰援 쓽怨쇰븰 븳由쇰븰援먯꽦떖蹂묒썝 吏꾨떒寃궗쓽븰怨 Tel: 031)380-3930, Fax: 031)380-3934, E-mail: lyoungk@hallym.or.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract

븳엫긽寃궗젙룄愿由ы삊쉶 씪諛섑삁븸寃궗 봽濡쒓렇옩뿉꽌뒗 쟾삁援ш퀎궛(complete blood count, CBC)怨 꽭룷삎깭뿉 븳 떊鍮숇룄議곗궗瑜 떆뻾븯떎. 珥 2쉶 떆뻾븯쑝硫, CBC뒗 留 쉶李 3媛 냽룄쓽 젙룄愿由щЪ吏덉쓣 諛곗넚븯怨, 꽭룷삎깭뒗 留 쉶李 2옣쓽 궗吏꾩쓣 쎒궗씠듃뿉 寃뚯떆븯떎. 씪諛섑삁븸寃궗뒗 珥 1,455湲곌씠 李몄뿬븯怨 CBC뒗 쉶떊쑉씠 96.3%쑝硫, 꽭룷삎깭寃궗뒗 쉶떊쑉씠 40.4%떎. 떊鍮숇룄議곗궗궗뾽뿉 궗슜맂 옣鍮꾩쓽 쁽솴 쟾뀈룄 鍮꾩듂븯떎. 諛깊삁援 닔, 쟻삁援 닔, 삁깋냼, 쟻삁援ъ슜쟻瑜, 삁냼뙋 닔쓽 蹂씠怨꾩닔(coefficient of variation)뒗 媛곴컖 3.8%-4.5%, 1.9%-2.3%, 1.4%-2.8%, 4.8%-5.8%, 6.2%-9.4% 踰붿쐞떎. 꽭룷삎깭뒗 紐⑤뱺 쉶李⑥뿉꽌 李몄뿬湲곌 媛꾩뿉 80% 씠긽쓽 씪移섏쑉쓣 蹂댁떎. 쟾뀈룄뿉 鍮꾪빐 2016뀈룄 쇅遺젙룄愿由ъ궗뾽 李몄뿬湲곌쓽 닔뒗 利앷븯쑝硫, 씪諛섑삁븸寃궗쓽 닔뻾뒫 쑀궗븯떎.

Under the Routine Hematology Program of Korean Association of External Quality Assessment Service, proficiency tests for complete blood count (CBC) and blood cell morphology were performed during 2016. We conducted two trials, and sent three level control materials for CBC testing and posted two cell morphology pictures on the website for each trial. Of 1,455 laboratories, the mean response rates for CBC and blood cell morphology were 96.3% and 40.4%, respectively. The distribution of equipment for CBC test was similar to that of previous year. The coefficient of variations for white blood cell counts, red blood cell counts, hemoglobin, hematocrit, and platelet counts, were 3.8%4.5%, 1.9%2.3%, 1.4%2.8%, 4.8%5.8%, and 6.2%9.4%, respectively. More than 80% of the blood cell morphology tests were concordant in all trials. In 2016, the number of participating laboratories increased, and the performance was similar to that of the previous year.

Keywords : Laboratory proficiency testing, Blood cell count, Blood cell morphology
꽌 濡

2016뀈 李⑥꽭 떊鍮숇룄議곗궗궗뾽씠 떆뻾릺뒗 泥ロ빐쑝硫, 씠 以 씪諛섑삁븸寃궗 봽濡쒓렇옩 쟾삁援ш퀎궛(complete blood count, CBC)怨 꽭룷삎깭(blood cell morphology) 2媛 寃궗빆紐⑹뿉 빐 뿰 2쉶 떆뻾븯떎. CBC뿉뒗 諛깊삁援 닔(white blood cell count), 쟻삁援 닔(red blood cell count), 삁깋냼(hemoglobin), 쟻삁援ъ슜쟻瑜(hematocrit), 삁냼뙋 닔(platelet count)瑜 룷븿븯룄濡 븯떎.

옱猷 諛 諛⑸쾿

씪諛섑삁븸寃궗 봽濡쒓렇옩뿉꽌뒗 CBC(諛깊삁援 닔, 쟻삁援 닔, 삁깋냼, 쟻삁援ъ슜쟻瑜, 삁냼뙋 닔) 꽭룷삎깭 2媛 寃궗빆紐⑹쓣 긽쑝濡 媛곴컖 6썡, 8썡 珥 2쉶 떎떆븯쑝硫, 媛 쉶李⑤떦 3媛쒖쓽 젙룄愿由щЪ吏덉쓣 룊媛븯룄濡 븯떎.

CBC瑜 쐞빐꽌뒗 CBC-4K Whole Blood Control (R&D System Inc., Minneapolis, MN, USA) 젙룄愿由щЪ吏덉쓣 씠슜븯떎. 媛 쉶李⑤쭏떎 궙 냽룄, 젙긽 냽룄, 넂 냽룄, 씠 3媛吏 냽룄쓽 젙룄愿由щЪ吏덈줈 援ъ꽦븯떎. 꽭룷삎깭寃궗瑜 쐞빐꽌뒗 媛 쉶李⑤쭏떎 2媛쒖쓽 꽭룷궗吏꾩쓣 媛꾨왂븳 엫긽냼寃ш낵 븿猿 솃럹씠吏뿉 寃뚯떆븯怨 李멸湲곌뿉꽌 뙋룆寃곌낵뿉 빐떦븯뒗 꽭룷삎깭寃궗 뙋룆肄붾뱶瑜 엯젰븯룄濡 븯떎.

젙룄愿由щЪ吏덉 怨꾩빟 깮諛곕 씠슜븯뿬 諛쒖넚븯뒗뜲, 1쉶李⑤뒗 6썡 27씪뿉, 2쉶李⑤뒗 8썡 30씪뿉 諛쒖넚븯떎. 寃궗寃곌낵뒗 李⑥꽭 떊鍮숇룄議곗궗궗뾽 솃럹씠吏뿉 엯젰븯룄濡 븯怨, 엯젰湲곌컙 醫낅즺 썑 엯젰寃곌낵뿉 빐 뜲씠꽣 삤瑜섎 寃利앺븳 썑 넻怨꾨텇꽍쓣 떆뻾븯떎.

CBC寃궗씤 諛깊삁援 닔, 쟻삁援 닔, 삁깋냼, 쟻삁援ъ슜쟻瑜, 삁냼뙋 닔 寃곌낵뒗 쟾泥 湲곌, 젣議고쉶궗蹂, 痢≪젙湲곌린蹂 넻怨꾨텇꽍쓣 떆뻾븯떎. 痢≪젙湲곌린蹂 遺꾩꽍뿉꽌뒗 쑀궗紐⑤뜽씤 寃쎌슦 븳 援곗쑝濡 臾띠뼱 넻怨꾨텇꽍쓣 떆뻾븯떎.

넻怨꾨텇꽍 룊洹, 몴以렪李(SD), 蹂씠怨꾩닔(coefficient of variation, CV), 以묎컙媛, 理쒖냼媛, 理쒕媛믪쓣 援ы븯쑝硫, 媛 湲곌뿉 빐 몴以렪李⑥닔(standard deviation index, SDI)瑜 궛젙븯떎[1]. 룊洹, SD, CV뒗 빐떦 遺꾨쪟蹂 遺꾩꽍뿉꽌 75 percentile 媛(Q3)怨 25 percentile 媛(Q1)쓽 李(Q3-Q1; interquartile range, IQR)쓽 1.5諛곕 珥덇낵븯뿬 Q1蹂대떎 궙嫄곕굹 Q3蹂대떎 넂 寃곌낵媛(Q3+1.5횞IQR) 씠긽移(outlier)濡 젣嫄고븳 썑 遺꾩꽍븯떎[2]. 媛 遺꾨쪟뿉 빐떦븯뒗 湲곌 닔媛 10媛 誘몃쭔씤 寃쎌슦뿉뒗 룊洹좉낵 SD, CV, SDI瑜 援ы븯吏 븡븯怨, 湲곌 닔媛 3媛 誘몃쭔씤 寃쎌슦뿉뒗 以묎컙媛믩룄 援ы븯吏 븡븯떎.

꽭룷삎깭寃궗뿉 븳 遺꾩꽍 媛 꽭룷蹂꾨줈 떟븳 湲곌 닔 諛깅텇쑉쓣 援ы븯떎. 媛 湲곌蹂 遺꾩꽍寃곌낵뒗 솃럹씠吏뿉꽌 吏곸젒 議고쉶 諛 異쒕젰븷 닔 엳룄濡 븯떎.

寃 怨

1. 떊鍮숇룄議곗궗궗뾽 李몄뿬湲곌

2016뀈 씪諛섑삁븸寃궗 봽濡쒓렇옩 珥 1,461湲곌씠 떊泥븯怨, 1쉶李⑥뿉 1,452湲곌, 2쉶李⑥뿉 1,458湲곌뿉 寃泥대 諛곗넚븯떎. CBC(諛깊삁援 닔, 쟻삁援 닔, 삁깋냼, 쟻삁援ъ슜쟻瑜, 삁냼뙋 닔) 寃곌낵瑜 쉶떊븳 湲곌 1쉶李 1,418湲곌, 2쉶李 1,383湲곌쑝濡 룊洹 寃곌낵 쉶떊쑉 96.3%떎. 꽭룷삎깭寃궗 寃곌낵瑜 쉶떊븳 湲곌 1쉶李 594湲곌, 2쉶李 582湲곌쑝濡 룊洹 寃곌낵 쉶떊쑉 40.4%떎(Table 1).

Table 1 . Response rate of laboratories that participated in proficiency tests performed under the Routine Hematology Program.

Manufacturer1st2ndMean%
긕ysmex60759360042.8
긏ihon Kohden Corp.135134134.59.6
긕iemens Healthcare Diagnostics Inc.1341281319.4
긕henzhen Mindray Bio-Medical Electronics Co. Ltd.1251251258.9
긅oriba Medical116113114.58.2
귻eckman Coulter Inc.113110111.58.0
귺bbott495049.53.5
귻oule2523241.7
긐rphee SA222121.51.5
긗RIT Medical Electronic Co. Ltd.988.50.6
긂rba Diagnostics5550.4
긕amsung Electronics544.50.3
귾irui Industrial2220.1
긕EAC S.R.L.2220.1
긘arian-31.50.1
긕henzhen Genius Electonics Co. Ltd.-31.50.1
긐thers6761644.6
긖otal1,4181,3831,401100.0

3. Complete blood count

諛깊삁援 닔쓽 쟾泥닿린愿 CV쓽 룊洹 媛믪 냽룄(HH-16-01 & HH-16-04) 3.9%, 以묎컙냽룄(HH-16-02 & HH-16-05) 4.2%, 怨좊냽룄(HH-16-03 & HH-16-06) 4.4%怨, 쟻삁援 닔쓽 쟾泥닿린愿 CV쓽 룊洹좉컪 냽룄(HH-16-01 & HH-16-04) 2.3%, 以묎컙냽룄(HH-16-02 & HH-16-05) 2.0%, 怨좊냽룄(HH-16-03 & HH-16-06) 1.9%떎. 삁깋냼쓽 쟾泥닿린愿 CV쓽 룊洹좉컪 냽룄(HH-16-01 & HH-16-04) 2.8%, 以묎컙냽룄(HH-16-02 & HH-16-05) 1.5%, 怨좊냽룄(HH-16-03 & HH-16-06) 1.8%怨, 쟻삁援ъ슜쟻瑜좎쓽 쟾泥닿린愿 CV쓽 룊洹좉컪 냽룄(HH-16-01 & HH-16-04) 5.5%, 以묎컙냽룄(HH-16-02 & HH-16-05) 4.9%, 怨좊냽룄(HH-16-03 & HH-16-06) 5.0%떎. 삁냼뙋 닔쓽 쟾泥닿린愿 CV쓽 룊洹좉컪 냽룄(HH-16-01 & HH-16-04) 8.8%, 以묎컙냽룄(HH-16-02 & HH-16-05) 6.9%, 怨좊냽룄(HH-16-03 & HH-16-06) 7.5%떎(Table 3).

Table 4. Proficiency test results for blood cell morphology.

TrialCodeMorphologyNo. (%)
HHI-16-01Total593 (100.0)
327Lymphocyte577 (97.3)
224Monocyte4 (0.7)
328Large granular lymphocyte2 (0.3)
330Lymphoma cell2 (0.3)
103Myelocyte2 (0.3)
104Metamyelocyte1 (0.2)
331Plasma cell1 (0.2)
449Polychromatic erythrocyte1 (0.2)
102Promyelocyte1 (0.2)
329Reactive lymphocyte1 (0.2)
106Segmented neutophil1 (0.2)
HHI-16-02Total594 (100.0)
438Nucleated red cell535 (90.1)
449Polychromatic erythrocyte22 (3.7)
331Plasma cell15 (2.5)
693Blast4 (0.7)
327Lymphocyte3 (0.5)
475Erythrocyte with overlying platelets2 (0.3)
460Howell-Jolly body2 (0.3)
454Spherocyte2 (0.3)
332Abnormal plasma cell1 (0.2)
120Dohle body1 (0.2)
330Lymphoma cell1 (0.2)
471Macrocyte1 (0.2)
103Myelocyte1 (0.2)
434Normal red cell1 (0.2)
102Promyelocyte1 (0.2)
690Sezary cell1 (0.2)
Not available1 (0.2)
HHI-16-03Total582 (100.0)
579Giant platelet468 (80.4)
327Lymphocyte48 (8.2)
224Monocyte14 (2.4)
223Immature monocyte11 (1.9)
689Hairy cell6 (1.0)
329Reactive lymphocyte5 (0.9)
110Basophil4 (0.7)
331Plasma cell4 (0.7)
449Polychromatic erythrocyte4 (0.7)
330Lymphoma cell3 (0.5)
102Promyelocyte3 (0.5)
573Megakaryocytic cell2 (0.3)
447Dimorphism1 (0.2)
116Faggot cell1 (0.2)
113Giant band neutrophil1 (0.2)
472Microcyte1 (0.2)
1.3Myelocyte1 (0.2)
438Nucleated red cell1 (0.2)
583Platelet aggregates1 (0.2)
690Sezary cell1 (0.2)
119Toxic granulation1 (0.2)
123Toxic vacuolation1 (0.2)
HHI-16-04Total582 (100.0)
105Band neutrophil543 (93.3)
106Segmented neutrophil29 (5.0)
108Eosinophil2 (0.3)
113Giant band neutrophil2 (0.3)
114Hypersegmented neutrophil2 (0.3)
109Immature basophil2 (0.3)
327Lymhocyte1 (0.2)
103Myelocyte1 (0.2)

4. 꽭룷삎깭

꽭룷삎깭뒗 留 쉶李⑤쭏떎 2媛쒖쓽 궗吏꾩쓣 寃뚯떆븯떎. 쟾泥 寃곌낵 쉶떊湲곌쓽 80% 씠긽 씪移섑븯뒗 寃곌낵瑜 湲곗쑝濡 룊媛븯쓣 븣, 1쉶李 HHI-16-01뒗 lymphocyte뿉 97.3%, 1쉶李 HHI-16-02뒗 nucleated red cell뿉 90.1%, 2쉶李 HHI-16-03 giant platelet뿉 80.4%, 2쉶李 HHI-16-04뒗 band neutrophil뿉 93.3% 씪移섏쑉쓣 蹂댁떎(Table 4).

怨 李

2016뀈 李⑥꽭 떊鍮숇룄議곗궗궗뾽 떆뻾뿉 뵲씪 씪諛섑삁븸寃궗 봽濡쒓렇옩룄 2015뀈怨쇰뒗 긽떦엳 떎瑜닿쾶 吏꾪뻾릺뿀떎[3]. 2015뀈뿉뒗 珥 4李⑥뿉 嫄몄퀜 留 쉶李⑤쭏떎 CBC뒗 젙룄愿由щЪ吏 1媛, 꽭룷삎깭뒗 궗吏 2媛쒖뵫 떆뻾릺뿀쑝굹, 2016뀈뿉뒗 2李⑥뿉 嫄몄퀜 留 쉶李⑤쭏떎 CBC뒗 젙룄愿由щЪ吏 3媛쒖뵫, 꽭룷삎깭뒗 궗吏 2媛쒖뵫 떆뻾븯떎.

2016뀈 씪諛섑삁븸寃궗 봽濡쒓렇옩뿉뒗 1,455湲곌씠 李몄뿬븯뿬 2015뀈쓽 룊洹 1,352湲곌뿉 鍮꾪빐 103湲곌(7.62%) 利앷븯怨, 利앷쑉룄 2015뀈쓽 0.67%뿉 鍮꾪빐 겙 룺쑝濡 利앷븯떎.

寃곌낵 쉶떊쑉 CBC뒗 96.3%濡 2015뀈쓽 97.2%뿉 鍮꾪빐 떎냼 궙쑝굹, 嫄곗쓽 鍮꾩듂븳 媛믪쓣 蹂댁떎. 꽭룷삎깭寃궗쓽 寃곌낵 쉶떊쑉 40.4%濡 2015뀈쓽 99.0% 긽떦븳 李⑥씠瑜 蹂댁뒗뜲, 씠뒗 2016뀈뿉뒗 CBC 꽭룷삎깭瑜 援щ텇븯吏 븡怨 씪諛섑삁븸 봽濡쒓렇옩쓣 떊泥븯硫 몢 寃궗빆紐 紐⑤몢 떊泥릺룄濡 븯쑝굹, 2015뀈뿉뒗 CBC 꽭룷삎깭瑜 媛곴컖 떊泥븯룄濡 븯뿬 꽭룷삎깭瑜 떊泥븳 湲곌씠 503湲곌쑝濡 옉븘 쉶떊쑉 넂寃 蹂댁씤 寃껋씠떎. 꽭룷삎깭 寃곌낵 쉶떊湲곌 닔瑜 鍮꾧탳븯硫 2016뀈뿉뒗 588湲곌, 2015뀈뿉뒗 503湲곌쑝濡 利앷븳 寃껋쑝濡 굹궗떎[3].

2016뀈 李⑥꽭 떊鍮숇룄議곗궗궗뾽뿉꽌뒗 紐⑤뱺 봽濡쒓렇옩뿉 빐 젙룄愿由щЪ吏덉쓽 諛쒖넚遺꽣 寃곌낵엯젰, 蹂닿퀬꽌 諛쒖넚源뚯 쟾 怨쇱젙쓣 븳엫긽寃궗젙룄愿由ы삊쉶(삊쉶) 以묒븰뿉꽌 씪愿릺寃 愿由, 吏꾪뻾븯떎. 寃泥 諛쒖넚 떎瑜 봽濡쒓렇옩쓽 젙룄愿由щЪ吏덇낵 븿猿 삁빟맂 깮諛곕줈 吏꾪뻾릺뿀떎. 1쉶李⑥뿉꽌뒗 2016뀈 5썡 2씪 CBC 젙룄愿由щЪ吏덉씠 諛쒖넚릺뿀쑝굹, 寃泥 슫넚怨쇱젙뿉꽌 슜삁씠 릺뒗 寃쎌슦媛 떎닔 諛쒖깮븯뿬 2016뀈 6썡 27씪 쟾硫댁쟻쑝濡 옱諛쒖넚쓣 떆뻾븯떎.

寃泥 닔졊 떆 媛 湲곌뿉꽌뒗 삊쉶 李⑥꽭 떊鍮숇룄議곗궗궗뾽 솃럹씠吏뿉꽌 寃泥 젒닔瑜 븳 썑, 寃궗瑜 떆뻾븯怨 寃곌낵瑜 솃럹씠吏뿉 吏곸젒 엯젰븳 썑, 理쒖쥌쟾넚쓣 빐빞 寃곌낵媛 쟾넚릺룄濡 븯떎. 엯젰湲곌컙 醫낅즺 썑 엯젰寃곌낵뿉 븯뿬 삤瑜섎 젏寃븯怨, 넻怨꾨텇꽍쓣 떆뻾븯쑝硫, 寃곌낵넻蹂 뿭떆 李⑥꽭 떊鍮숇룄議곗궗궗뾽 솃럹씠吏뿉꽌 李몄뿬湲곌蹂꾨줈 吏곸젒 議고쉶 諛 異쒕젰쓣 븷 닔 엳룄濡 븯떎. 寃곌낵蹂닿퀬꽌뒗 怨듯넻蹂닿퀬꽌 湲곌蹂꾨낫怨좎꽌 몢 媛吏 삎깭濡 젣怨듯븯쑝硫, 怨듯넻蹂닿퀬꽌뿉뒗 쟾泥닿린愿, 洹몃━怨, 젣議곗궗蹂, 湲곌린蹂 넻怨꾨 젣怨듯븯떎. 湲곌蹂 蹂닿퀬꽌뿉꽌뒗 媛 湲곌쓽 寃곌낵媛믨낵 쟾泥, 洹몃━怨 湲곌뿉꽌 궗슜븯뒗 湲곌린쓽 젣議곗궗, 湲곌린遺꾨쪟뿉 뵲瑜 넻怨꾧컪怨 SDI瑜 젣怨듯븯쑝硫, 쟾泥닿린愿 諛 룞씪 젣議곗궗瑜 궗슜븯뒗 湲곌뱾뿉꽌 빐떦 湲곌쓽 寃곌낵媛믪쓽 쐞移섎 엳뒪넗洹몃옩쑝濡 젣怨듯븯怨, 빐떦 湲곌쓽 SDI쓽 늻쟻遺꾪룷瑜 洹몃옒봽濡 몴떆븯뿬 젣怨듯븯떎(Fig. 1).

Figure 1.

Summary report of routine hematology program. (A) Summary of all participants. (B) Summary of each laboratory.


넻怨꾨텇꽍 떆 냼닔젏 몴떆 李⑹삤 벑 엯젰삤瑜섎줈 뙋떒릺뒗 寃껋 닔湲곕줈 젣쇅븯怨, 씠긽移섏뿉 빐떦븯뒗 寃곌낵媛믪 Turkey쓽 box-plot諛⑹떇쓣 씠슜븳 궗遺꾩쐞踰[3]쓽 씠긽移 젣嫄곕 쟻슜븯뿬 넻怨꾨텇꽍뿉꽌 젣쇅븯떎. 넻怨꾨쾾쐞뿉 뱾뼱삤뒗 湲곌留뚯쓣 긽쑝濡 룊洹좉낵 SD, CV瑜 怨꾩궛븯쑝硫, 媛 湲곌쓽 룊媛寃곌낵뒗 SDI濡 젣떆븯떎. 씠뿉 뵲씪 씪諛섑삁븸寃궗쓽 넻怨꾨텇꽍 젣쇅湲곌 1李⑥뿉꽌뒗 3.9%-7.8%, 2李⑥뿉꽌뒗 2.0%-6.8%떎(Table 3).

CBC뿉 궗슜맂 湲곌린쓽 쁽솴 Sysmex (Japan)媛 42.8%濡 媛옣 留롮븯怨, 떎쓬쑝濡, Nihon Kohden Corp. (Japan), Siemens Healthcare Diagnostics Inc. (USA), Shenzhen Mindray Bio-Medical Electronics Co. Ltd. (China), Horiba Medical (France), Beckman Coulter Inc. (USA) 벑씠 遺꾪룷븯뿬 二쇱슂 궗슜湲곌린쓽 遺꾪룷뒗 2015뀈怨 쑀궗븳 냼寃ъ씠뿀떎[3].

닔뻾뒫 痢〓㈃뿉꽌 CBC쓽 諛깊삁援 닔, 쟻삁援 닔, 삁깋냼, 쟻삁援ъ슜쟻瑜, 삁냼뙋 닔쓽 CV뒗 媛곴컖 3.8%-4.5%, 1.9%-2.3%, 1.4%-2.8%, 4.8%-5.8%, 6.2%-9.4% 踰붿쐞濡, 2015뀈쓽 媛 寃궗빆紐⑹쓽 CV 4.13%, 1.89%, 1.92%, 5.02%, 8.10% 鍮꾩듂븳 遺꾪룷떎[3]. 꽭룷삎깭뒗 紐⑤뱺 쉶李⑥뿉꽌 李몄뿬湲곌 媛꾩뿉 80% 씠긽쓽 씪移섏쑉쓣 蹂댁떎.

2016뀈 씪諛섑삁븸寃궗 봽濡쒓렇옩 李⑥꽭 떊鍮숇룄議곗궗궗뾽 떆뻾뿉 뵲씪 쟾 怨쇱젙씠 쟾泥 봽濡쒓렇옩怨 븿猿 삊쉶 以묒븰뿉꽌 씪愿 떆뻾릺뿀쑝硫, 떆뻾슏닔 媛 쉶李⑥쓽 젙룄愿由щЪ吏 닔룄 蹂寃쎈릺뿀뿀떎. 李몄뿬湲곌 쟾뀈뿉 鍮꾪빐 긽떦븳 利앷瑜 蹂댁쑝硫, 닔뻾뒫 痢〓㈃뿉꽌뒗 鍮꾩듂븳 寃곌낵瑜 蹂댁떎.

References
  1. Kwon GC, Kim J, Ra GS. Diagnostic Hematology Subcommittee; Korean Association of External Quality Assessment Service. Annual report on the external quality assessment for diagnostic hematology in Korea (2015). J Lab Med Qual Assur 2016;38:1-10.
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  2. Klee GG, Westgard JO. Quality management. In: Burtis CA, Ashwood ER, Bruns DE, editors. Teitz textbook of clinical chemistry and molecular diagnostics. 5th ed. St. Louis (MO): Elsevier Saunders, 2012:163-203.
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  3. Turkey JW. Exploratory data analysis. Reading (MA): Addison-Wesley, 1977.