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슂 諛 蹂옞삁寃궗 떊鍮숇룄議곗궗 寃곌낵蹂닿퀬(2016)
Annual Report on the External Quality Assessment Scheme for Urinalysis and Faecal Occult Blood Testing in Korea (2016)
J Lab Med Qual Assur 2017;39:117-123
Published online September 30, 2017
© 2017 Korean Association of External Quality Assessment Service.

쟾李쏀샇, 씠븘吏, 源긽寃, 꽌뿄꽍, 諛곗쁺泥
Chang-Ho Jeon, A-Jin Lee, Sang-Gyung Kim, Hun-Seok Suh, Young-Cheol Bae

援ш넧由븰援 쓽怨쇰븰 吏꾨떒寃궗쓽븰援먯떎

Department of Laboratory Medicine, Daegu Catholic University School of Medicine, Daegu, Korea
Correspondence to: Chang-Ho Jeon Department of Laboratory Medicine, Daegu Catholic University Medical Center, 33 Duryugongwon-ro 17-gil, Nam-gu, Daegu 42472, Korea Tel: +82-53-650-4144 Fax: +82-53-653-8672 E-mail: chjeon@cu.ac.kr
援먯떊옄: 쟾李쏀샇 슦)42472 援ъ떆 궓援 몢瑜섍났썝濡 17湲 33, 援ш넧由븰援먮퀝썝 吏꾨떒寃궗쓽븰怨 Tel: 053)650-4144, Fax: 053)653-8672, E-mail: chjeon@cu.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract

2016뀈 슂寃쎄 諛 蹂옞삁寃궗(faecal occult blood, FOB) 젙룄愿由ъ궗뾽씠 1,487媛 湲곌씠 李몄뿬븯뿬 떆뻾릺뿀떎. 슂솕븰寃궗 3쉶, FOB寃궗 2쉶뿉 嫄몄퀜 떆뻾릺뿀怨, 궗吏꾪뙋룆뿉 쓽븳 슂移⑥궗臾 뙋젙 1쉶 떎떆븯떎. 슂솕븰寃궗뒗 pH, protein, glucose, ketone, bilirubin, blood, urobilinogen, nitrite, leukocyte 諛 specific gravity (SG) 벑 10빆紐⑹씠뿀떎. 슂솕븰寃궗 諛 슂떆뿕吏遊됱뿉 쓽븳 SG寃궗뒗 95% 씠긽쓽 슦닔븳 젙떟瑜좎쓣 굹궡뿀쑝굹, 슂移⑥궗臾쇨궗뒗 transitional epithelial cell 諛 鍮꾩젙삎 寃곗젙泥댁뿉꽌 궙 젙떟瑜좎쓣 蹂댁떎. FOB 젙꽦寃궗뿉꽌 90% 씠긽쓽 젙떟瑜좎쓣 蹂댁뿬 쓬꽦 寃泥댁뿉꽌 굹궃 쐞뼇꽦 寃곌낵媛 媛쒖꽑릺뿀떎. FOB 젙웾寃궗뒗 옣鍮 媛꾩뿉 냽룄李⑥씠瑜 蹂댁쑝硫, 蹂 뼇 궗슜뿉 뵲瑜 냽룄李⑥씠瑜 蹂댁셿븯湲 쐞븯뿬 關g/g of stool濡 蹂닿퀬븷 븘슂媛 젣湲곕릺뿀떎.

In 2016, external quality assessment trials for urinalysis and faecal occult blood (FOB) were performed with 1,487 participants in Korea. Urine chemistry and FOB tests were performed three and two times, respectively, whereas urine sediment was evaluated once using photography. Urine chemistry tests consisted of pH, protein, glucose, ketone, bilirubin, blood, urobilinogen, and nitrite levels; leukocyte count; specific gravity. The results of the urine chemistry and specific gravity tests showed accuracy rates of >95%. The accuracy rate of urine sediments was low, especially that for transitional epithelial cells and atypical crystals. In the FOB quality test, all reagents showed accuracy rates of >90%, which suggested the improvement of false-positive reaction. In the FOB quantitative test, discrepant results depending on the instrument used was observed. To compensate for the result differences caused by the stool samples, the results should be reported using another unit (關g/g of stool).

Keywords : Quality assessment, Urinalysis, Occult blood
꽌 濡

슂寃쎄븰遺꾧낵쓽 2016뀈룄 쇅遺젙룄愿由ъ궗뾽 깉濡쒖슫 쟾궛엯젰떆뒪뀥쓣 룄엯븯뿬 떆뻾릺뿀떎. 깉濡쒖슫 쟾궛떆뒪뀥쓽 룄엯릺뿀쑝굹 寃곌낵遺꾩꽍 諛 蹂닿퀬媛 쟻떆뿉 씠猷⑥뼱吏吏 븡븘 留롮 湲곌뿉꽌 遺덊렪쓣 샇냼븯떎. 씠윴 臾몄젣媛 뒭 媛먯씠 엳吏留 紐⑤몢 빐寃곕릺뼱 븯諛섍린뿉뒗 옒 吏꾪뻾맆 닔 엳뿀떎. 2015뀈 떊鍮숇룄議곗궗궗뾽뿉꽌 蹂옞삁寃궗(faecal occult blood, FOB)뒗 쓬꽦 寃泥댁뿉꽌 11.0%-72.3%쓽 젙떟瑜좎쓣 굹궡뿀怨, 슂移⑥궗뙋룆뿉꽌 82.6%-98.1%쓽 젙떟瑜좎쓣 媛곴컖 굹궡뼱[1] 젙떟瑜좎씠 媛옣 궙븯뜕 FOB쓽 쐞뼇꽦 臾몄젣瑜 蹂댁셿븯怨좎옄 븯떎.

뵲씪꽌 2016뀈 쇅遺젙룄愿由ъ궗뾽쓣 쐞븯뿬 3李⑥뿉 嫄몄퀜 12媛쒖쓽 愿由щЪ吏덉쓣 궗슜븯뿬 슂솕븰寃궗瑜 떆뻾븯怨, 슂移⑥궗寃궗뒗 1쉶 4媛쒖쓽 臾쇱쭏濡 떆뻾븯떎. 삉븳 2쉶뿉 嫄몄퀜 6媛쒖쓽 愿由щЪ吏덉쓣 궗슜븯뿬 FOB瑜 떆뻾븯떎. 슂솕븰寃궗 諛 FOB 떊鍮숇룄議곗궗뿉뒗 援궡뿉꽌 젣議곕맂 愿由щЪ吏덉쓣 궗슜븯떎. 슂移⑥궗寃궗뒗 슂移⑥궗 궗吏 4留ㅻ 蹂 삊쉶 솃럹씠吏뿉 寃뚯떆븯뿬 뙋룆븯룄濡 븯떎.

옱猷 諛 諛⑸쾿

1. 긽

슂寃쎄븰遺꾧낵뿉꽌뒗 븳엫긽寃궗젙룄愿由ы삊쉶뿉 벑濡앸맂 湲곌쓣 긽쑝濡 2016뀈룄 4썡, 6썡, 8썡 3李⑥뿉 嫄몄퀜 젙룄愿由щЪ吏덉쓣 諛쒖넚븯떎. 諛쒖넚湲곌 닔뒗 1,487湲곌쑝濡 15뀈룄 1,265湲곌뿉 鍮꾪븯뿬 222湲곌씠 利앷릺뿀쑝硫 쉶떊쑉 97.8%떎.

2. 옱猷

슂솕븰寃궗瑜 쐞븳 愿由щЪ吏덉 1李(CU-16-01-04), 2李(CU-16-05-08), 3李(CU-16-09-12) 寃泥 紐⑤몢 援궡뿉꽌 젣議고븳 븸긽愿由щЪ吏 4醫낆뵫쓣 媛 쉶썝湲곌뿉 깋옣 룷옣븯뿬 諛쒖넚븯떎. 씠 以 2李⑥뿉뒗 븸긽 寃泥 쇅뿉 蹂 삊쉶 솃럹씠吏뿉 젣떆븳 슂移⑥궗 궗吏 4留 벑 紐⑤몢 22醫낆쓽 寃泥대 슦넚 諛 젣떆븯뿬 젙룄愿由 떊鍮숇룄議곗궗瑜 떆뻾븯떎. 寃곌낵移섏쓽 엯젰 蹂 삊쉶뿉꽌 깉濡寃 援ъ텞맂 떊鍮숇룄議곗궗궗뾽 솃럹씠吏뿉꽌 吏곸젒 엯젰븯뒗 諛⑹떇쓣 궗슜븯떎. FOB瑜 쐞븳 愿由щЪ吏덈룄 1李 諛 2李 寃泥 紐⑤몢 援궡뿉꽌 젣議고븳 젏븸꽦 遺꾨쭚愿由щЪ吏 3醫(CS-16-01-06)쓣 媛 쉶썝湲곌뿉 깋옣 룷옣븯뿬 諛쒖넚븯떎.

3. 젙룄愿由щЪ吏덉쓽 뿀슜移

슂솕븰 諛 FOB寃궗쓽 寃쎌슦 遺꾧낵쐞썝쉶뿉꽌 떎뿕븳 李멸퀬移, 媛 湲곌뿉꽌 쉶떊븳 寃곌낵쓽 씪移섎룄瑜 怨좊젮븯쑝硫, 媛뒫븯硫 쟾湲곌쓽 95%-99%媛 뿀슜踰붿쐞뿉 뱾뼱삱 닔 엳룄濡 뿀슜移섎 꽕젙븯떎. FOB 諛 援댁젅怨꾩뿉 쓽븳 鍮꾩쨷 룊洹졖2SD쓽 踰붿쐞瑜 뿀슜踰붿쐞濡 꽕젙븯떎.

寃곌낵

1. 슂솕븰寃궗 9醫낆쓽 떊鍮숇룄議곗궗 꽦쟻

슂솕븰寃궗 9醫(pH, protein, glucose, ketone, bilirubin, blood, urobilinogen, nitrite, leukocyte)쓽 떊鍮숇룄議곗궗 꽦쟻 Table 1뿉 슂빟븯떎. Table 1 1李 諛 3李⑥쓽 紐⑤뱺 젙룄愿由 寃泥댁쓽 룊洹 젙떟瑜좎쓣 援ы븳 옄猷뚯씠硫, 紐⑤뱺 빆紐⑹뿉꽌 97% 씠긽쓽 젙떟瑜좎쓣 굹궡뿀떎.

Table 1 . Number of participants and acceptable rates of urine chemistry QC.

꺿꺿긖ests1st QC2nd QC3rd QC



ParticipantsAcceptable (%)ParticipantsAcceptable (%)ParticipantsAcceptable (%)
pH1,26498.01,27698.81,28099.0
Protein1,26998.11,27999.11,28399.1
Glucose1,26598.11,27699.11,28098.8
Ketone1,24199.51,24999.61,25399.6
Bilirubin1,24298.91,24999.11,25399.2
Blood1,26597.61,27699.61,28098.1
Urobilinogen1,24399.21,24999.51,25399.3
Nitrite1,22499.01,23199.31,23499.3
Leukocyte1,21997.71,22398.41,22698.2

Abbreviation: QC, quality control..


2. 슂솕븰 遺꾩꽍湲곗뿉 뵲瑜 슂솕븰寃궗 떊鍮숇룄議곗궗 꽦쟻

媛 쉶궗蹂 슂솕븰 遺꾩꽍湲곗뿉 뵲瑜 슂솕븰寃궗쓽 떊鍮숇룄議곗궗 꽦쟻 Table 2 媛숇떎. YD (YD Diagnostics, Yongin, Korea)媛 39.8%濡 媛옣 留롮씠 궗슜븯怨 엳쑝硫, SD (Standard Diagnostics, Seoul, Korea) 15.8%, Roche (Roche, Mannheim, Germany) 15.2%, DFI (DFI Co. Ltd., Gimhae, Korea) 8.6% 닚씠뿀떎. 쉶궗蹂 옣鍮꾩뿉 뵲씪 슂솕븰寃궗쓽 젙떟瑜좎 李⑥씠瑜 蹂댁씠吏 븡븯쑝굹 Beckman 옣鍮(Beckman Coulter Inc., Brea, CA, USA)뒗 諛깊삁援 寃異쒖뿉꽌 75%쓽 궙 젙떟瑜좎쓣 굹궡뿀쑝硫, 씠뒗 諛깊삁援 뼇꽦 寃泥대 쓬꽦쑝濡 뙋룆븳 뜲꽌 湲곗씤븯떎.

Table 2 . Acceptable rates according to the urine chemistry analysers of different companies.

CompanypHProteinGlucoseKetoneBilirubinBloodUrobilinogenNitriteLeukocyteTotal (%)
YD98.398.799.299.799.899.599.699.498.3507 (39.8)
SD98.198.598.299.199.695.399.099.396.7201 (15.8)
Roche99.499.599.799.399.599.499.899.599.4194 (15.2)
DFI98.797.696.599.699.398.099.599.097.9109 (8.6)
Siemens99.7100.099.799.796.699.997.799.199.484 (6.6)
Eiken95.698.999.199.894.899.499.799.499.752 (4.1)
Arkray100.0100.0100.0100.099.899.899.8100.099.639 (3.0)
Beckman100.0100.0100.098.099.393.1100.099.575.07 (0.5)
Others98.397.696.299.999.297.398.699.797.380 (5.8)

Values are presented as % or number (%)..

The instruments used were from the following companies: YD (YD Diagnostics, Yongin, Korea), SD (Standard Diagnostics, Seoul, Korea), Roche (Roche diagnostics, Mannheim, Germany), DFI (DFI Co. Ltd., Gimhae, Korea), Siemens (Siemens Healthcare (Erlangen, Germany), Eiken (Eiken Chemical Co., Tokyo, Japan), Arkray (Arkray Inc., Kyoto, Japan), and Beckman (Beckman Coulter Inc., Brea, CA)..


3. 슂솕븰 遺꾩꽍湲곕줈 떆뻾븳 슂鍮꾩쨷寃궗 떊鍮숇룄議곗궗 꽦쟻

슂鍮꾩쨷寃궗뒗 援댁젅怨 寃궗뒗 떆뻾븯吏 븡怨 슂솕븰 遺꾩꽍 옣湲곕줈 痢≪젙븯떎. Table 3뿉꽌 媛숈씠 紐⑤뱺 寃泥댁뿉꽌 95% 씠긽쓽 젙떟瑜좎쓣 굹궡뿀떎.

Table 3 . Acceptable rates for the urine specific gravity test.

SpecimenParticipantsMean짹SD95% Confidence intervalAcceptable (%)
CU-16-011,2101.005짹0.0291.001 to 1.01597.0
CU-16-021,2101.009짹0.0041.005 to 1.01597.7
CU-16-031,2091.007짹0.0411.005 to 1.01595.3
CU-16-041,2051.021짹0.0061.010 to 1.03098.8
CU-16-051,2221.006짹0.0031.000 to 1.01297.6
CU-16-061,2241.009짹0.0041.001 to 1.01698.3
CU-16-071,2241.009짹0.0041.001 to 1.01696.5
CU-16-081,2241.021짹0.0061.009 to 1.03498.9
CU-16-091,2321.006짹0.0031.000 to 1.01397.2
CU-16-101,2321.008짹0.0041.001 to 1.01597.9
CU-16-111,2321.009짹0.0041.002 to 1.01696.2
CU-16-121,2321.021짹0.0061.009 to 1.03498.3

4. 궗吏 寃泥대 씠슜븳 슂移⑥궗臾 寃궗寃곌낵

궗吏 寃泥대 궗슜븯뿬 떆뻾븳 슂移⑥궗臾 떊鍮숇룄議곗궗쓽 룊洹 젙떟瑜좎 8.7%뿉꽌 86.7%쓽 젙떟瑜좎쓣 蹂댁떎(Table 4). Transitional epithelial cell 諛 renal tubular epithelial cell쓣 monocyte 샊 macrophage濡 뙋젙븯떎. 삉븳 sulfonamide 諛 calcium oxalate 寃곗젙泥댁쓽 떇蹂꾩 뜑슧 궙 젙떟瑜좎쓣 蹂댁떎. Sulfonamide 寃곗젙泥대뒗 옄二 愿李곕릺吏 븡븘꽌 79.4%, calcium oxalate 寃곗젙泥대뒗 鍮꾩젙삎 삎깭媛 異쒖젣릺뼱 媛옣 궙 8.7%쓽 젙떟瑜좎쓣 蹂댁떎.

Table 4 . Acceptable rates for the urine sediment examination.

꺿꺿긓eplied resultsSpecimen no.Value
Sulfonamide*CUI-16-01639
Ca oxalateCUI-16-0168
BilirubinCUI-16-0138
Correct answer (%)CUI-16-0179.4
Transitional epi cell*CUI-16-02461
Monocyte/macrophageCUI-16-02105
Renal tubular epi cell*CUI-16-0285
Correct answer (%)CUI-16-0267.8
Cellular cast*CUI-16-03698
Granular castCUI-16-0341
RBC/pigmented castsCUI-16-0321
Correct answer (%)CUI-16-0386.7
LeucineCUI-16-04368
Starch granuleCUI-16-04322
Calcium oxalate*CUI-16-0470
Correct answer (%)CUI-16-048.7
No. of participants805

Values are presented as number, unless otherwise stated..

*Correct answer.


5. FOB 떆빟뿉 뵲瑜 FOB 젙꽦寃궗쓽 젙떟瑜 諛 떆빟쓽 遺꾪룷

FOB 떆빟뿉 뵲瑜 FOB 젙꽦寃궗쓽 젙떟瑜좎 Table 5뿉 굹궡뿀떎. 떆빟 SD FOB Rapid test (261湲곌), YD FOB test (115湲곌), Asan FOB easy test (Asan Pharmaceutical, Seoul, Korea; 58湲곌), Eiken homocatch light (Eiken Chemical Co., Tokyo, Japan; 56湲곌) 닚쑝濡 궗슜븯떎. 紐⑤뱺 떆빟뿉꽌 뼇샇븳 젙떟瑜좎쓣 굹궡뿀쑝굹, FOB 쓬꽦 寃泥댁뿉꽌 GC genedia FOB (Green Cross Medial Science Co., Yongin, Korea; 90.9%), Humasis FOB test (Humasis Co., Anyang, Korea; 91.4%), YD FOB test (93.9%) 떆빟뿉꽌 떎냼 궙 젙떟瑜좎쓣 굹궡뿀떎.

Table 5 . Acceptable rates for the faecal occult blood quality test.

꺿꺿긓eagentsNo.CS-16-01CS-16-02CS-16-03



NegativeAcceptable (%)PositiveAcceptable (%)PositiveAcceptable (%)
SD FOB Rapid test26125095.8261100.026099.6
YD Occult Tech FOB test11510893.9115100.0115100.0
ASAN Easy Test FOB585696.658100.058100.0
Eiken Hemocatch light565598.25598.25598.2
Humasis FOB test353291.435100.035100.0
Bio Focus FOB Rapid test3333100.033100.033100.0
HBI HiSens FOB NCard3131100.031100.031100.0
GC Genedia FOB222090.922100.022100.0
Others131076.913100.013100.0

Abbreviation: FOB, faecal occult blood..

The instruments used were from the following companies: SD (Standard Diagnostics, Seoul, Korea), YD (YD Diagnostics, Yongin, Korea), Asan Pharmaceutical (Seoul, Korea), Eiken Chemical Co. (Tokyo, Japan), Humasis Co. (Anyang, Korea), Bio Focus Co. (Uiwang, Korea), HBI Co. (Anyang, Korea), and GC (Green Cross Medial Science Co., Yongin, Korea)..


6. FOB 떆빟뿉 뵲瑜 FOB 젙웾寃궗쓽 젙떟瑜 諛 떆빟쓽 遺꾪룷

FOB 젙웾寃궗寃곌낵 遺꾪룷뒗 Table 6뿉 슂빟븯떎. 옣鍮꾨퀎濡 寃궗뿉 궗슜븯뒗 蹂 뼇씠 떖씪꽌 옣鍮 媛 鍮꾧탳媛 뼱젮썙 씠踰덉뿉뒗 씠瑜 蹂댁젙븳 媛믪쓣 븿猿 鍮꾧탳븯떎. 궗슜옣鍮꾨뒗 Eiken (156湲곌), Alfresa (Alfresa Pharma Co., Osaka, Japan; 49湲곌), Kyowa (Kyowa Chemical Industry Co., Kagawa, Japan; 34湲곌) 닚쑝濡 遺꾪룷븯떎. 쟾泥 룊洹좎뿉 鍮꾪븯뿬 Alfresa 옣鍮꾨뒗 CS-16-01 諛 CS-16-04 寃泥댁뿉꽌 넂 닔移섎 蹂댁떎. 삉븳 Alfresa 옣鍮꾨뒗 CS-16-02, 16-03, 16-05 諛 16-06 寃泥댁뿉꽌 紐⑤몢 궙 냽룄瑜 굹궡뿀떎.

Table 6 . Distribution of the results of the faecal occult blood quantitation tests.

InstrumentsSpecimen no.No.MedianMinimumMaximumAverage




ng/mL쨉g/g stoolng/mL쨉g/g stoolng/mL쨉g/g stoolng/mL쨉g/g stool
EikenCS-16-0115620.410.2255.05.41.1
AlfresaCS-16-01495410.330.611020.949.29.3
KyowaCS-16-013411.011.077.01.51.5
OthersCS-16-011425.0NA1NA28NA17NA
EikenCS-16-0215616432.8459.030561.0160.132.0
AlfresaCS-16-024914527.67915.018034.2140.126.6
KyowaCS-16-02343434.01010.05151.035.835.8
OthersCS-16-0214143NA5NA498NA177.6NA
EikenCS-16-0315636673.211422.8624124.8360.272.0
AlfresaCS-16-034927852.87814.845887.0272.951.9
KyowaCS-16-033468.568.52323.0122122.074.274.2
OthersCS-16-0314385.5NA43NA1,000NA365.9NA
EikenCS-16-0415551.000.0428.45.61.1
AlfresaCS-16-0448529.961.19918.846.98.9
KyowaCS-16-043522.000.077.01.81.8
OthersCS-16-041125NA4NA72NA24.9NA
EikenCS-16-0515515531.0204.042585.0156.631.3
AlfresaCS-16-0548124.523.75510.525648.6128.824.5
KyowaCS-16-05353737.01313.05757.034.734.7
OthersCS-16-0511157NA18NA413NA158.4NA
EikenCS-16-0615527555.08216.4584116.8275.455.1
AlfresaCS-16-064821340.58315.838873.7216.441.1
KyowaCS-16-06356565.02121.09898.063.163.1
OthersCS-16-0611239NA40NA916NA308.5NA

Abbreviation: NA, not available..

The instruments used were from the following companies: Eiken Chemical Co. (Tokyo, Japan), Alfresa Pharma Co. (Osaka, Japan), and Kyowa Chemical Industry Co. (Kagawa, Japan)..


怨좎같

2016뀈쓽 젙룄愿由 떊鍮숇룄議곗궗뿉꽌 굹궃 寃곌낵瑜 遺꾩꽍빐 蹂 븣 2015뀈 젙룄愿由 떊鍮숇룄궗뾽寃곌낵뿉 鍮꾪븯뿬 슂솕븰寃궗 諛 鍮꾩쨷寃궗뒗 슦닔븳 젙떟瑜좎쓣 쑀吏븯떎. 洹몃윭굹 슂移⑥궗 떊鍮숇룄議곗궗뿉꽌룄 2015뀈 젙떟瑜 80.1%-98.1%蹂대떎 궙 寃곌낵瑜 蹂댁떎. FOB 젙꽦寃궗뿉꽌 2015뀈蹂대떎뒗 留ㅼ슦 슦닔븳 젙떟瑜좎쓣 蹂댁뿬 쐞뼇꽦瑜좎씠 룺 媛먯냼븯떎.

슂솕븰寃궗뿉꽌 9醫낆쓽 寃궗빆紐⑹뿉꽌 leukocytes瑜 젣쇅븯怨 옣鍮 媛 寃곌낵李⑥씠瑜 蹂댁씠吏 븡븯떎. Beckman 옣鍮꾩뿉꽌 leukocytes 뼇꽦씤 寃泥대 쓬꽦쑝濡 뙋룆븯떎. 슂솕븰寃궗쓽 젙룄愿由 寃泥대뒗 phosphate buffered saline뿉 뼇꽦 臾쇱쭏쓣 泥④븯뿬 젣議고븳 寃껋씠떎. Leukocytes 뼇꽦 臾쇱쭏 怨듦컻릺吏 븡븘 븣 닔 뾾吏留, 湲곗쭏뿉 쓽븳 媛꾩꽠쁽긽쑝濡 쓬꽦 寃곌낵瑜 蹂댁씠뒗 寃껋쑝濡 깮媛곷릺뿀떎. 뼢썑 湲곗쭏뿉 쓽븳 媛꾩꽠쁽긽쓣 諛⑹븷 닔 엳뒗 젙룄愿由щЪ吏덉쓣 궗슜븯뒗 寃껋쑝濡 媛쒖꽑븷 븘슂꽦씠 엳떎.

슂移⑥궗 떊鍮숇룄議곗궗뿉꽌뒗 궙 젙떟瑜좎쓣 湲곕줉븯뒗뜲 transitional epithelial cell쓣 monocyte 샊 macrophage濡 뙋젙븯떎. Fig. 1뿉꽌 愿李곕맂 諛붿 媛숈씠 떎빑꽭룷瑜 蹂댁뿬 삤빐븷 닔 엳쑝굹 寃곗꽍利앹씠굹 移댁꽭꽣瑜 궫愿븳 솚옄뿉꽌뒗 醫낆쥌 떎빑쓣 蹂댁씠뒗 transitional epithelial cell쓣 蹂 닔 엳떎[2]. Sulfonamide 寃곗젙泥대뒗 sulphonamide 蹂듭슜 솚옄굹 솕긽 移섎즺젣濡 벐씠뒗 sliver sulfadiazine 궗슜 떆 굹굹硫[3], calcium oxalate 寃곗젙泥대뒗 鍮꾩젙삎 삎깭媛 異쒖젣릺뼱 留ㅼ슦 궙 젙떟瑜좎쓣 蹂댁떎. Calcium oxalate 寃곗젙泥대뒗 냼蹂뿉꽌 媛옣 쓷븳 寃곗젙泥댁씠硫 鍮꾩젙삎 삎깭룄 옄二 굹굹誘濡[4,5] 씠뿉 븳 二쇱쓽媛 븘슂븯떎.

Figure 1.

Images of urine sediments (with arrow) for the external quality assessment. (A) ZCUI-16-01 sulfadiazine crystal (original magnification 횞400). (B) CUI-16-02 transitional epithelial cell (original magnification 횞200). (C) CUI-16-03 white blood cell count cast (original magnification 횞100). (D) CUI-16-04 calcium oxalate crystal (original magnification 횞400).


FOB 젙꽦寃궗뿉꽌 2015뀈뿉뒗 쟾 떆빟뿉꽌 쓬꽦 寃泥대 뼇꽦쑝濡 뙋룆븯뿬 삤떟瑜좎씠 89.0%뿉 떖븯뿬 臾몄젣젏쑝濡 遺媛곷릺뿀떎. 씠瑜 쐞븯뿬 援궡 떆뙋릺뒗 二쇱슂 FOB 젙꽦寃궗 떆빟쓣 긽쑝濡 솚옄 寃泥대 궗슜븯뿬 꽦뒫寃궗瑜 떆뻾븯뿬 11 ng/mL 씠긽씪 븣 14.3%-57.1%쓽 뼇꽦瑜좎쓣 蹂댁떎. 젙꽦떆빟쓽 FOB 寃異 誘쇨컧룄뒗 20 ng/mL 씠긽쑝濡 븣젮졇 엳떎[6]. 젙꽦떆빟쓽 怨쇰룄븳 誘쇨컧룄瑜 궙異붽린 쐞븯뿬 援궡 FOB 떆빟쉶궗뱾뿉寃 誘쇨컧룄 議곗젙쓣 슂泥븯怨 2016뀈뿉 2쉶뿉 嫄몄퀜 FOB 쓬꽦씤 寃泥대줈 떊鍮숇룄議곗궗궗뾽쓣 떆뻾븳 寃곌낵 紐⑤몢 90% 씠긽쓽 젙떟瑜좎쓣 蹂댁떎. 씪떒 떊鍮숇룄議곗궗 꽦쟻뿉꽌뒗 쐞뼇꽦 臾몄젣媛 빐寃곕맂 寃껋쑝濡 蹂댁씠굹 떆뙋릺뒗 FOB 떆빟쓣 궗슜븯뿬 誘쇨컧룄 媛쒖꽑 뿬遺瑜 솗씤븷 븘슂꽦씠 엳떎.

蹂옞삁 젙웾寃궗뿉꽌 Alfresa뒗 냽룄 寃泥댁뿉꽌뒗 넂寃, 以묐벑 諛 怨좊냽룄 寃泥댁뿉꽌뒗 궙寃 痢≪젙븯떎. FOB 젙룄愿由 寃泥대뒗 媛뺣젰遺 諛媛猷⑥뿉 삁깋냼 遺꾨쭚쓣 泥④븯뿬 젣議고븳 寃껋씠떎. 寃泥 湲곗쭏뿉 뵲瑜 쁺뼢쓣 諛곗젣븷 닔뒗 뾾쑝굹, 옣鍮꾩뿉 뵲瑜 寃곌낵 李⑥씠뒗 떎瑜 뿰援ъ옄뱾뿉 쓽빐꽌룄 蹂닿퀬릺뿀떎[7]. FOB 젙웾寃궗뒗 痢≪젙옣鍮꾩뿉 뵲씪꽌 궗슜릺뒗 蹂 뼇씠 떖씪꽌 ng/mL쓽 떒쐞濡 蹂닿퀬븯硫 二쇱엯릺뒗 蹂 뼇쑝濡 씤븳 냽룄李⑥씠瑜 蹂댁씪 닔 엳떎. 뼢썑 FOB쓽 삉 떎瑜 蹂닿퀬떒쐞씤 關g/g stool쓣[8] 룄엯븯뿬 蹂묓뻾븯뿬 궗슜븿쑝濡쒖뜥 씠 臾몄젣瑜 빐寃고븯怨좎옄 븳떎.

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