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Establishing Reference Intervals for Complete Blood Cell Count in Healthy Korean Elderly Individuals
J Lab Med Qual Assur 2018;40:27-37
Published online March 31, 2018
© 2018 Korean Association of External Quality Assessment Service.

Eun Jin Lee, Miyoung Kim, Eunyup Lee, Kibum Jeon, Jiwon Lee, Han-Sung Kim, Hee Jung Kang, and Young Kyung Lee

Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
Correspondence to: Miyoung Kim
Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang 14068, Korea
Tel: +82-31-380-1795
Fax: +82-31-380-1798
Received November 30, 2017; Revised January 15, 2018; Accepted February 1, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Different age groups may have different reference intervals. However, the currently used reference interval for complete blood count (CBC) in clinical laboratories is based on results from healthy adults between 20 and 50 years of age. In this study, we aimed to establish reference intervals for 16 CBC parameters in Korean healthy elderly individuals.
Methods: A total of 3,359 healthy adults were selected from 4,253 adults (aged 돟20 years) who underwent regular health check-ups, based on a medical examination by interview. The reference intervals for CBC in two groups (aged 竊60 and 돟60 years), and the partitioning of reference intervals between the two age groups were established.
Results: Most CBC parameters showed no significant differences in reference intervals between the two age groups. Among the men, platelet distribution width (PDW) was the only parameter that required a separate reference interval between the two age groups. Among the women, mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and eosinophil % required separate reference intervals between the two age groups.
Conclusions: The reference intervals for most CBC parameters were not significantly different between the two age groups. Except for PDW in men and MCV, MCHC, RDW, and eosinophil % in women, reference intervals for CBC parameters in individuals younger than 60 years of age could also be applied to those that are 60 years of age or older.
Keywords : Complete blood cell count, Elderlies, Reference interval
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