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Accuracy-Based Proficiency Testing of Creatinine Measurement: 7 Years’ Experience in Korea
J Lab Med Qual Assur 2019;41:13-23
Published online March 31, 2019
© 2019 Korean Association of External Quality Assessment Service.

Tae-Dong Jeong1 , Hye Ah Lee2 , Kyunghoon Lee3 , and Yeo-Min Yun4

1Department of Laboratory Medicine, Ewha Womans University School of Medicine; 2 Clinical Trial Center, Ewha Womans University Mokdong Hospital, Seoul; 3 Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam; 4 Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea
Correspondence to: Tae-Dong Jeong, Department of Laboratory Medicine, Ewha Womans University School of Medicine, 25 Magokdong-ro 2-gil, Gangseogu, Seoul 07804, Korea Tel: +82-2-6986-3386 Fax: +82-2-6986-3389 E-mail: tdjeong@ewha.ac.kr
Received November 29, 2018; Revised December 27, 2018; Accepted January 7, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Background: Standardization of creatinine assay is consistently performed and much effort has been put into improving the accuracy of the results. We aimed to analyze the results of accuracy-based proficiency testing of creatinine assays performed by the Korea Association of External Quality Assessment Service from 2011 to 2017 to assess the current state of creatinine assays in Korea.
Methods: From 2011 to 2017, the accuracy-based proficiency testing of creatinine was performed twice a year. We analyzed the results obtained from the participating laboratories and calculated the year-wise bias. The acceptable limit of bias was as follows: ±11.4% for creatinine concentration >1.0 mg/dL, and 0.114 mg/dL for creatinine concentration ≤1.0 mg/ dL. The trend of bias with the major instruments and reagent manufacturers were analyzed.
Results: The number of participating laboratories was 54 in 2011, which gradually increased to 146–178 after 2015. For each of the three samples used in the survey, the percentage of laboratories whose biases in the results were within the acceptable limits was 33.3% for the first time in 2011, which gradually increased to 74.7%–85.0% after 2014. The mean biases in all the results of the participating laboratories were 11.1% in 2011 (1st trial) and 2.4% in 2017 (2nd trial). The biases in the results with the major instruments and reagents differed according to the manufacturers.
Conclusions: The mean bias in the results obtained from the participating laboratories in the accuracy-based proficiency testing of creatinine surveys showed a decreasing trend.
Keywords : Accuracy, Bias, Creatinine, Proficiency testing