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Annual Report

J Lab Med Qual Assur 2014; 36(4): 161-170

Published online December 31, 2014

https://doi.org/10.15263/jlmqa.2014.36.4.161

Copyright © Korean Association of External Quality Assessment Service.

Annual Report on External Quality Assessment of Viral Markers and Serological Tests for Syphilis in Korea (2013)

Jun Hyung Lee1, Young Joo Cha1, Jae Hoon Bae1, and Seok Lae Chae2, as Immunoserology Subcommittee, The Korean Association of Quality Assurance for Clinical Laboratory

1Department of Laboratory Medicine, Chung-Ang University Hospital, Chung- Ang University College of Medicine, Seoul; 2Department of Laboratory Medicine, Dongguk University Ilsan Hospital, Dongkuk University College of Medicine, Goyang, Korea

Correspondence to:Young Joo Cha
Department of Laboratory Medicine, Chung-Ang University College of Medicine, 84 Heukseok-ro, Dongjak-gu, Seoul 156-861, Korea
Tel: +82-2-6299-2720
Fax: +82-2-6298-8630
E-mail: chayoung@cau.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We performed two trials on the external quality assessment of viral markers and serological tests for syphilis (STS) organised by the Immunoserology Subcommittee of the Korean Association of Quality Assurance for Clinical Laboratories in 2013. In each trial, we delivered 3 kinds of pooled sera specimens to 1,021 institutions for external proficiency testing. Pooled sera were checked for their homogeneity and stability by using more than 3 other methods between the day of their manufacture and 3 days after despatching. The numbers of participating laboratories were 1,019 (99.8%) and 1,020 (99.8%) for the first and second trials, respectively. The most commonly tested items were hepatitis B surface antigen followed by antibody to hepatitis B surface antigen, anti-human immunodeficiency virus, anti-hepatitis C virus, STS, and anti-hepatitis B core. The most frequently used methods for detecting viral markers were the chemiluminescence immunoassay (CLIA) and the electrochemiluminescence immunoassay, which generated a few false positive results. In contrast, false negative results were frequently found through the immunochromatography assay, the use of which for detecting viral markers has been steadily increasing in recent years. The new tests, turbidoimmunoassay and CLIA, have recently been introduced for the measurement of non-treponemal and treponemal antibodies, and their use is also increasing. (J Lab Med Qual Assur 2014;36:161-170)

Keywords: Hepatitis B, Hepatitis C, HIV, Immunoassay, Laboratory proficiency testing, Serology, Syphilis

References

  1. Cha YJ, Kwon SY, Kim TY, Kim JR, Kim HS, Park MH, et al. Annual report on external quality assessment in immunoserology in Korea (2009). J Lab Med Qual Assur 2010;32:45-68.
  2. Cha YJ, Kwon SY, Kim TY, Kim JR, Kim HS, Park MH, et al. Annual report on external quality assessment in immunoserology in Korea (2005). J Lab Med Qual Assur 2006;28:41-61.
  3. Cha YJ, Kwon SY, Kim TY, Kim JR, Kim HS, Park MH, et al. Annual report on external quality assessment in immunoserology in Korea (2006). J Lab Med Qual Assur 2007;29:45-64.
  4. Cha YJ, Kwon SY, Kim TY, Kim JR, Kim HS, Park MH, et al. Annual report on external quality assessment in immunoserology in Korea (2007). J Lab Med Qual Assur 2008;30:49-74.
  5. Cha YJ, Kwon SY, Kim TY, Kim JR, Kim HS, Park MH, et al. Annual report on external quality assessment in immunoserology in Korea (2008). J Lab Med Qual Assur 2009;31:49-72.
  6. Cha YJ, Kwon SY, Kim TY, Kim JR, Kim HS, Park MH, et al. Annual report on external quality assessment in immunoserology in Korea (2012). J Lab Med Qual Assur 2013;34:51-89.
  7. Goh BT, van Voorst Vader PC; European Branch of the International Union against Sexually Transmitted Infection and the European Office of the World Health Organization. European guideline for the management of syphilis. Int J STD AIDS 2001;12 Suppl 3:14-26.
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