Receiver operating characteristic curve analysis of new algorithm for differentiating mechanical hemolysis and immune-mediated hemolysis (A) Mechanical hemolysis group vs. immune-mediated hemolysis group. (B) Normal control group+mechanical hemolysis group vs. immune-mediated hemolysis group. (A) Efficiency of differentiating between mechanical hemolysis and immune-mediated hemolysis (cut-off, 9; sensitivity, 91.7%; specificity, 92.9%; AUC, 0.965 [95% CI, 0.924–0.988]). (B) Efficiency of differentiating between sum of normal control and mechanical RBC hemolysis and immune-mediated RBC hemolysis (cut-off, 9; sensitivity, 91.7%; specificity, 93.7%; AUC, 0.968 [95% CI, 0.935–0.987]). Abbreviations: AUC, area under the curve; CI, confidence interval; RBC, red blood cell.