Table. 2.

Results of cardiac marker proficiency test for subgroups during the 2020-2nd EQA program

Test substance Instrument No. of labs CCA-20-04 (pooled human serum) CCA-20-05 (pooled human serum) CCA-20-06 (commercial control material)



Mean±SD CV (%) Mean±SD CV (%) Mean±SD CV (%)
TnI All 362 0.179±0.138 77.1 0.227±0.174 76.8 5.220±2.696 51.6*
ADVIA Centaur XPT 12 0.362±0.029 8.1 0.468±0.038 8.0 17.602±0.671 3.8
ARCHITECT i1000 22 0.360±0.026 7.1 0.452±0.033 7.3 7.359±0.549 7.5
ARCHITECT i2000 56 0.365±0.024 6.7 0.452±0.03 6.7 7.142±0.435 6.1
UniCel DxI800 34 0.022±0.002 10.0 0.026±0.002 9.2 5.253±0.196 3.7
Pathfast 33 0.051±0.007 14.4 0.068±0.009 13.9 4.839±0.507 10.5
AFIAS-6 17 0.175±0.015 8.3 0.220±0.018 8.2 9.704±0.835 8.6
AQT90 FLEX 52 0.022±0.002 8.2 0.026±0.003 10.8 1.153±0.057 5.0
cobas4000 e411 41 0.164±0.032 19.5 0.207±0.032 15.5 3.945±0.332 8.4
cobas6000 e601 17 0.159±0.021 13.2 0.200±0.024 12.2 3.596±0.175 4.9
TnT All 114 0.156±0.006 3.7 0.197±0.007 3.6 1.674±0.531 31.7*
cobas e801 29 0.157±0.005 3.0 0.199±0.005 2.5 2.116±0.162 7.7
cobas4000 e411 51 0.156±0.006 4.0 0.199±0.009 4.4 1.124±0.129 11.5
cobas6000 e601 15 0.154±0.005 3.3 0.196±0.007 3.3 2.05±0.209 10.2
cobas8000 e602 19 0.153±0.006 3.7 0.194±0.005 2.6 2.028±0.2 9.9
BNP All 85 NA NA NA NA 1,382.0±167.3 12.1
ARCHITECT i2000 23 NA NA NA NA 1,414.4±143.6 10.2
UniCel DxI800 15 NA NA NA NA 1,265.5±41.5 3.3
Triage Meter-pro 15 NA NA NA NA 615.4±109.5 17.8
NT-proBNP All 296 6,295.9±360.3 5.7 8,020.3±412.7 5.2 4,604.6±2,399.0 52.1*
cobas e801 38 6,042.1±162.9 2.7 7,795.5±199.2 2.6 3,287.5±122.7 3.7
cobas4000 e411 68 6,282.7±228.1 3.6 8,134.6±330.7 4.1 2,705.3±161.5 6.0
cobas6000 e601 29 6,242.5±221.6 3.6 7,922.2±225.4 2.8 3,415.1±236.6 6.9
cobas8000 e602 26 6,158.7±183.8 3.0 7,958.3±238.3 3.0 3,425.1±240.4 7.0
Pathfast 28 5,820.1±657.0 11.3 7,588.7±712.5 9.4 10,402.2±808 7.8
AQT90 FLEX 45 6,462.3±250.2 3.9 8,115.8±365.4 4.5 6,767.2±291.2 4.3
AFIAS-6 10 6,623.4±540.9 8.2 8,660.5±678.1 7.8 20,055.5±1,957.2 9.8
ARCHITECT i2000 16 7,335.1±336.9 4.6 9,370.6±464.8 5.0 4,120.6±232.2 5.6

The instruments used in 10 or more institutions during the 2020-2nd EQA program are presented in the table. The level of BNP, which in ethylenediaminetetraacetic acid-plasma is a suitable specimen recommended by the test manufacturer, was measured in commercial material only. The instruments used were from the following companies: Siemens (Tarrytown, NY, USA), Abbott (Abbott Park, IL, USA), Beckman Coulter (Brea, CA, USA), Polymedco (Cortlandt Manor, NY, USA), Boditech Med Inc. (Chuncheon, Korea), Radiometer (Brønshøj, Denmark), Roche (Mannheim, Germany), and Quidel Corp. (San Diego, CA, USA).

Abbreviations: EQA, external quality assessment; SD, standard deviation; CV, coefficient of variation; TnI, troponin I; TnT, troponin T; BNP, brain natriuretic peptide; NA, not available; NT-proBNP, N-terminal pro-brain natriuretic peptide.

*CCA-20-06, the commercial control material with high concentration of cardiac marker, showed higher CV% compared to other materials.

Lab Med Qual Assur 2021;43:176~184 https://doi.org/10.15263/jlmqa.2021.43.4.176
© Lab Med Qual Assur