Laboratory Medicine and Quality Assurance

Table. 4.

Matrix-related biases for FSPs based on the different assays

Analyte Assay pair (x–y) Bias (%bias)

FSP1 FSP2 FSP3 FSP4 FSP5
Alpha-fetoprotein Roche-Abbott 2.60 (1.55) 10.18 (7.63) 5.33 (5.77) –8.45 (–18.06) 6.78 (27.42)
Roche-Siemens 6.60 (3.99) 5.67 (4.32) 2.76 (3.08) –10.09 (–23.11) 4.73 (22.09)
Roche-Beckman 0.25 (0.14) 7.65 (5.25) –0.89 (–0.93) –15.47 (–37.34) –5.62 (–37.71)
Abbott-Siemens 3.96 (2.43) –4.65 (–3.84) –2.68 (–3.18) –1.63 (–3.13) –2.22 (–15.37)
Abbott-Beckman –2.88 (–1.57) –4.59 (–3.44) –7.29 (–8.11) –5.27 (–10.21) –13.74 (–203.21)
Siemens-Beckman –7.57 (–4.23) 1.03 (0.74) –3.95 (–4.23) –3.13 (–5.81) –10.83 (–112.00)
Carcinoembryonic antigen Roche-Abbott 0.73 (2.01) 3.41 (17.76) 0.97 (6.55) 0.47 (4.70) 0.95 (21.72)
Roche-Siemens 3.52 (14.49) 2.49 (20.03) 1.35 (14.47) 0.62 (10.37) –0.90 (–44.9)
Roche-Beckman 4.38 (10.97) 2.64 (12.57) 2.77 (17.17) 2.50 (23.17) 0.54 (12.17)
Abbott-Siemens 3.11 (13.02) 0.38 (3.65) 0.97 (10.85) 0.63 (10.56) –1.17 (–67.38)
Abbott-Beckman 3.43 (8.79) –1.57 (–9.35) 1.26 (8.62) 1.49 (15.28) –1.08 (–38.43)
Siemens-Beckman –0.75 (–2.14) –0.36 (–2.00) 1.66 (11.05) 2.67 (24.38) 3.24 (45.38)
Prostate-specific antigen Roche-Abbott 5.43 (5.31) –0.33 (–0.46) 0.39 (0.85) 1.35 (5.21) 0.19 (1.63)
Roche-Siemens –2.54 (–3.02) –1.94 (–3.33) –1.42 (–3.73) 0.02 (0.07) 0.02 (0.15)
Roche-Beckman 0.58 (0.45) 8.17 (9.22) –4.14 (–7.19) 3.28 (10.11) 1.02 (6.83)
Abbott-Siemens –6.97 (–8.75) –1.66 (–2.84) –1.73 (–4.59) –1.08 (–5.28) –0.15 (–1.45)
Abbott-Beckman –6.24 (–5.13) 8.59 (9.64) –4.63 (–8.11) 1.59 (5.18) 0.78 (5.29)
Siemens-Beckman 4.47 (3.38) 11.14 (12.15) –1.97 (–3.30) 3.26 (10.04) 1.00 (6.71)

Abbreviation: FSP, frozen human serum pools

Lab Med Qual Assur 2022;44:111~120 https://doi.org/10.15263/jlmqa.2022.44.2.111
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