Laboratory Medicine and Quality Assurance

Table. 1.

Patient serum sample concentrations and measured coefficient of variations with different assays

Assay Traceability Median (range) (ng/mL) Total CV (%)
Alpha-fetoprotein WHO 72/225 IS
Abbott 124.81 (1.97–729.56) 1.6
Beckman 125.82 (2.34–926.51) 4.3
Roche 131.67 (2.07–927.67) 1.3
Siemens 118.67 (2.00–737.83) 2.5
Carcinoembryonic antigen WHO 73/601 IS
Abbott 31.28 (2.02–158.18) 2.2
Beckman 31.14 (1.78–195.78) 4.9
Roche 29.30 (2.08–161.00) 1.5
Siemens 19.78 (1.57–143.24) 2.4
Prostate-specific antigen WHO 96/670 IS
Abbott 13.69 (4.02–238.16) 2.9
Beckman Hybritech standard 16.69 (4.84–299.33) 4.8
Roche 15.07 (4.33–247.67) 2.1
Siemens 10.61 (3.47–188.93) 1.9

The instruments used were from Abbott Laboratories (Abbott Park, IL, USA), Beckman Coulter Inc. (Brea, CA, USA), Roche Diagnostics (Mannheim, Germany), and Siemens Healthineers (Erlangen, Germany)

Abbreviations: CV, coefficient of variation; WHO, World Health Organization; IS, international standard

Lab Med Qual Assur 2022;44:111~120 https://doi.org/10.15263/jlmqa.2022.44.2.111
© Lab Med Qual Assur