Laboratory Medicine and Quality Assurance

Table. 4.

Recovery of levetiracetam and lamotrigine measurements using ultra-high performance liquid chromatography-tandem mass spectrometry

Items Assigned (μg/mL) Mean±SD (μg/mL) CV (%) Recovery (%)
Levetiracetam 0.60 0.60±0.01 1.91 99.33
1.20 1.21±0.02 1.50 101.17
4.80 4.80±0.06 1.24 100.00
24.00 25.33±0.38 1.49 105.53
96.00 96.74±1.57 1.62 100.77
120.00 121.74±2.98 2.45 101.45
230.00 224.41±5.37 2.39 97.57
340.00 340.13±6.68 1.96 100.04
Lamotrigine 0.175 0.17±0.01 7.76 96.00
0.35 0.36±0.02 6.32 104.00
1.40 1.38±0.09 6.35 98.29
7.00 7.26±0.16 2.23 103.77
28.00 28.50±0.57 2.01 101.79
35.00 34.13±0.18 0.54 97.53
67.50 64.99±1.76 2.71 96.28
100.00 99.98±3.29 3.30 99.98

Abbreviations: SD, standard deviation; CV, coefficient of variation.

Lab Med Qual Assur 2022;44:226~229 https://doi.org/10.15263/jlmqa.2022.44.4.226
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