Annual Report on the External Quality Assessment Scheme for Biochemical Genetics in Korea (2015)

Soo-Youn Lee; Ok Ja Ji; Gye Cheol Kwon; Jong- Won Kim; Hyung-Doo Park; Junghan Song; Sang- Guk Lee; Yong-Wha Lee; Eun Hee Lee; Sail Chun; Tae Youn Choi; as the Biochemical Genetics Subcommittee; Korean Association of External Quality Assessment Service

doi:10.15263/jlmqa.2016.38.2.68

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Annual Report

J Lab Med Qual Assur 2016; 38(2): 68-76

Published online June 30, 2016

https://doi.org/10.15263/jlmqa.2016.38.2.68

Annual Report on the External Quality Assessment Scheme for Biochemical Genetics in Korea (2015)

Soo-Youn Lee¹, Ok Ja Ji¹, Gye Cheol Kwon², Jong- Won Kim¹, Hyung-Doo Park¹, Junghan Song³, Sang- Guk Lee⁴, Yong-Wha Lee⁵, Eun Hee Lee⁶, Sail Chun⁷, and Tae Youn Choi⁸, as the Biochemical Genetics Subcommittee, Korean Association of External Quality Assessment Service

¹Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul;
²Department of Laboratory Medicine, Chungnam National University Hospital, Daejeon;
³Department of Laboratory Medicine, Seoul Natinal University Bundang Hospital, Seongnam;
⁴Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul;
⁵Department of Laboratory Medicine and Genetics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon;
⁶Green Cross Laboratories, Yongin;
⁷Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine;
⁸Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea

Correspondence to:Soo-Youn Lee
Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
Tel: +82-2-3410-1834
Fax: +82-2-3410-2719
E-mail: suddenbz@skku.edu

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

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Two external quality assessment (EQA) trials of conventional newborn screening tests for phenylketonuria, galactosemia, congenital adrenal hyperplasia, maple syrup urine disease, homocystinuria, and congenital hypothyroidism, as well as newborn screening tests using tandem mass spectrometry, were performed in 2015. A total of 44 specimens in the form of dried blood spots were distributed to 16 laboratories and the response rate of these laboratories was 100%. The mean, standard deviation, coefficient of variation, median, and cut-offs were evaluated for each analyte in the newborn screening tests. Two EQA trials for the analyses of methylmalonic acid, vanillylmandelic acid, catecholamines, metanephrines, organic acids, and amino acids were also performed. A well-designed EQA program and continuous education would improve the performance of biochemical genetics tests. (J Lab Med Qual Assur 2016;38:68-76)

Keywords: External quality assessment, Newborn screening, Tandem mass spectrometry, Biochemical genetics

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Song J, Kwon KC, Kim JH, Kim JW, Min WK, Lee SY, et al. Annual report on external quality assessment in metabolic disorders in Korea (2007). J Lab Med Qual Assur 2008;30:151-66.
Lee SY, Kwon KC, Kim JH, Kim JW, Park BT, Park HD, et al. Annual report on external quality assessment in biochemical genetics in Korea (2011). J Lab Med Qual Assur 2012;34:S25-49.
Lee SY, Kwon KC, Kim JH, Kim JW, Park BT, Park HD, et al. Annual report on external quality assessment in biochemical genetics in Korea (2012). J Lab Med Qual Assur 2013;35:S29-63.
Lee SY; Biochemical Genetics Subcommittee, The Korean Association of Quality Assurance for Clinical Laboratory. Annual report on external quality assessment of biochemical genetics in Korea (2013). J Lab Med Qual Assur 2014;36:64-70.
Lee SY. Annual report on external quality assessment in biochemical genetics in Korea (2014). J Lab Med Qual Assur 2015;37:56-63.