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pISSN 2950-9114 eISSN 2950-9122
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Report On Proficiency Testing

Lab Med Qual Assur 2022; 44(3): 143-158

Published online September 30, 2022


Copyright © Korean Association of External Quality Assessment Service.

Report of the Korean Association of External Quality Assessment Service on Metabolite Testing in Korea (2020–2021)

Soo-Youn Lee1 and Sunhyun Ahn2,*

1Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; 2Department of Laboratory Medicine, Seoul Clinical Laboratories, Yongin, Korea

Correspondence to:Soo-Youn Lee
Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea
Tel +82-2-3410-1834
E-mail suddenbz@skku.edu
*Current affiliation: The author is now with the Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


External quality assessment (EQA) trials of conventional newborn screening tests for phenylketonuria, galactosemia, congenital adrenal hyperplasia, maple syrup urine disease, homocystinuria, and congenital hypothyroidism, as well as extended newborn screening tests using tandem mass spectrometry, were performed twice in 2020 and 2021. Up to 10 dried blood spot specimens for each test item were analyzed in each trial in 15 laboratories. The median, mean, standard deviation, minimum and maximum values, and cut-off values were evaluated for each analyte in newborn screening tests. The proportion of correct answers was 91%–100%. EQA trials for the analysis of methylmalonic acid, vanillylmandelic acid, catecholamines, metanephrines, organic acids, and amino acids were also performed using two or three specimens per trial. A well-designed EQA program and continuous education can help improve metabolite testing performance.

Keywords: External quality assessment, Newborn screening, Tandem mass spectrometry, Amino acid, Organic acid, Metabolite

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