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pISSN 2950-9114 eISSN 2950-9122
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Original Article

Lab Med Qual Assur 2023; 45(4): 149-155

Published online December 31, 2023


Copyright © Korean Association of External Quality Assessment Service.

Performance Evaluation of the Beckman Coulter DxH 900 Automated Hematology Analyzer

Shinae Yu1,* , Ja Young Lee2,* , Eunkyoung You2 , Sae Am Song1 , Jeong Nyeo Lee1 , and Kyung Ran Jun1

1Department of Laboratory Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine; 2Department of Laboratory Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea

Correspondence to:Kyung Ran Jun
Department of Laboratory Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, 875 Haeun-daero, Haeundae-gu, Busan 48108, Korea
Tel +82-51-797-3191
E-mail jun@paik.ac.kr
*These authors contributed equally to this study as first authors.

Received: August 10, 2023; Revised: September 30, 2023; Accepted: October 16, 2023

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background: The Beckman Coulter DxH 900 hematology analyzer (Beckman Coulter Inc., USA) is based on the Coulter Principle and accurately counts and measures the size of cells by monitoring changes in the electrical resistance of cells in a conductive liquid. Monocyte distribution width (MDW) is a new parameter of the DxH 900 analyzer that assists in the early diagnosis of sepsis. We evaluated the analytical performance of the DxH 900 for all parameters, including MDW.
Methods: We evaluated the precision, linearity, and carryover-related performance of the DxH 900, and analyzed the correlation between the DxH 900 and XE-2100 (Sysmex Corp., Japan) analyzers for all parameters (except MDW).
Results: The DxH 900 demonstrated acceptable precision for measuring normal and abnormal high- and low-level quality controls. The MDW repeatability was good (coefficient of variation of 3.99%–6.68%). White blood cells, red blood cells, hemoglobin, and platelets exhibited excellent linearity at high and low ranges, and no carryover effect was seen. The results obtained from the DxH 900 and XE-2100 analyzers were highly correlated.
Conclusions: The parameters including MDW of the DxH 900 analyzer showed good analytical performance and reproducibility. The parameters correlated well with the existing model, XE-2100. Our study demonstrated that the DxH 900 is useful in routine laboratories.

Keywords: Hemoglobins, Monocyte distribution width, Performance evaluation, Automated hematology analyzer

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